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The Primal Blueprint: Reprogram your genes for effortless weight loss, vibrant health, and boundless energy by Mark Sisson is a journey through human evolution, comparing the life and robust health of our hunter-gatherer ancestors with a day in the life of a modern family. The author offers a solution in 10 empowering Blueprint Lifestyle Laws: eat lots of plants and animals, avoid poisonous things, move frequently at a slow pace, lift heavy things, sprint once in a while, get adequate sleep, play, get adequate sunlight, avoid stupid mistakes, and use your brain. The reader learns how the right high-fat diet can actually help one lose weight and how popular low-fat, grain-based diets might trigger illness, disease, and lifelong weight gain. The author presents a comprehensive, well thought out paleo style eating plan in a humorous and organized manner. He backs up all his work with research, natural wisdom, and historical timelines. He disputes the role of dietary saturated fat in causation of arteriosclerosis, the role of cholesterol in promotion of heart disease, and the costly over-promotion of expensive, potentially toxic statin drugs. He criticizes our massive overeating of refined carbohydrates and urges avoidance of grains, cereals, bread and sugar. There is specific recommendation for "primal" food including more natural healthy fats and meats, fruits, veggies, and nuts. Some reviewers consider this to be the best of the various paleo books. The many Amazon reviews average to 5 stars. The author's popular and worthwhile web site: Mark's Daily Apple. The 2nd Edition was published January 14, 2012.
The WHO trial (so named because the international team of principal investigators contained World Health Organization members) tested the potential of clofibrate, a “pre-statin” cholesterol-lowering agent, to reduce heart attack morbidity and mortality. The investigators ultimately concluded that clofibrate "cannot be recommended as a lipid-lowering drug for community-wide primary prevention of ischaemic heart disease.” Nevertheless, clofibrate remained in use until 2002, when it was pulled for increasing cancer rates. In their review of studies such as the WHO trial, Uffe Ravnskov and David Diamond observe, “Despite the largely disappointing findings from 50 years of cholesterol lower[ing] trials, the indictment and conviction of cholesterol as the causal agent in CVD [cardiovascular disease] has stood the test of time. … [Yet] the grand effort to reduce cholesterol as a strategy to improve health has failed.”
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