To the outside world, though, as Glassman's company has exploded from a cult fitness website to a gym concept primed to have more locations than Curves by the end of 2013, CrossFit can appear risky, unhinged: Here is a fitness routine that has sent people to the hospital, overseen by people who may have had no more than two days of instruction. (Although every real trainer I met had considerable experience and was genuinely excellent, I attended the seminar and passed the test on my fourth day reporting this story. I am, believe me, no fitness savant.) And it's all led by a man who, in a 2006 CrossFit.com comment, wrote, "We have a therapy for injuries at CrossFit called STFU." As in, Shut the f-k up. That's enough to make even the most devoted laissez faire-ists get a little, well, Uncle Pukie.
Gluten is a protein found in things like rye, wheat, and barley. It’s now being said that much of our population may be gluten-intolerant (hence all the new “gluten-free!” items popping up everywhere). Over time, those who are gluten intolerant can develop a dismal array of medical conditions from consuming gluten: dermatitis, joint pain, reproductive problems, acid reflux, and more.
Good Calories, Bad Calories: Fats, Carbs, and the Controversial Science of Diet and Health by Gary Taubes expounds on his 2002 article in the NY Times (What if It's All Been a Big Fat Lie?) and then in Science Magazine (see below). He shows how public health data has been misinterpreted to mark dietary fat and cholesterol as the primary causes of coronary heart disease. Deeper examination, he says, shows that heart disease and other diseases of civilization appear to result from increased consumption of refined carbohydrates: sugar, white flour and white rice. Or in other words, without using the word Paleolithic, he justifies the paleo diet. Here is an excellent chapter by chapter summary of the book [archive.org].
The digestive abilities of anatomically modern humans, however, are different from those of Paleolithic humans, which undermines the diet's core premise. During the 2.6 million year-long Paleolithic era, the highly variable climate and worldwide spread of human populations meant that humans were, by necessity, nutritionally adaptable. Supporters of the diet mistakenly presuppose that human digestion has remained essentially unchanged over time.
Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.