This biggest success of Week 2 was attending a happy hour networking event completely sober. I headed there with a friend who was also doing Whole30, and we vowed to be each other's support system. We ordered seltzer waters together and proudly said no to the cheeseburger sliders and cheese board. Leaving the event, I felt empowered knowing I had it in me to refuse alcohol and fatty food, something I'd never tried before. Plus, I now knew I didn't have to use alcohol as a social crutch.

Whole30 is a nutritional program designed to change the way you feel and eat in 30 days. Basically, you have to remove all of the potentially inflammatory foods and beverages in your diet (think: added sugar and sweeteners, alcohol, grains, legumes, dairy, processed foods and beverages, baked goods, and junk foods) and eat three "clean" meals a day, made with Whole30-approved ingredients (think: meats, seafood, veggies, and eggs).
So what does the science say about the paleo diet? Some research suggests that the health claims hold truth. A review analyzed four randomized, controlled trials with 159 participants, and researchers found that the paleo diet led to more short-term improvements in some risk factors for chronic disease (including waist circumference and fasting blood sugar) compared with other control diets. (4)
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In my first CrossFit experience three years ago, I almost made myself puke because I wanted so badly to finish with a good time. Last year, I did another CrossFit workout that I hadn’t properly prepared for and cranked out 100 pull ups quickly…and I ended up walking around with T-rex arms for a WEEK because I physically could not straighten them. Not kidding.
Trying to devise an ideal diet by studying contemporary hunter-gatherers is difficult because of the great disparities that exist; for example, the animal-derived calorie percentage ranges from 25% for the Gwi people of southern Africa to 99% for the Alaskan Nunamiut.[39] Descendants of populations with different diets have different genetic adaptations to those diets, such as the ability to digest sugars from starchy foods.[39] Modern hunter-gatherers tend to exercise considerably more than modern office workers, protecting them from heart disease and diabetes, though highly processed modern foods also contribute to diabetes when those populations move into cities.[39]
Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.
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