In 2011, the Games adopted an online qualification format, facilitating participation by athletes worldwide. During the five-week-long "CrossFit Open", one new workout is released each week. Athletes have several days to complete the workout and submit their scores online, with either a video or validation by a CrossFit affiliate. Since the Open is available to any level of athlete, many affiliates encourage member participation and the number of worldwide participants can be in the hundreds of thousands.
The WHO trial (so named because the international team of principal investigators contained World Health Organization members) tested the potential of clofibrate, a “pre-statin” cholesterol-lowering agent, to reduce heart attack morbidity and mortality. The investigators ultimately concluded that clofibrate "cannot be recommended as a lipid-lowering drug for community-wide primary prevention of ischaemic heart disease.” Nevertheless, clofibrate remained in use until 2002, when it was pulled for increasing cancer rates. In their review of studies such as the WHO trial, Uffe Ravnskov and David Diamond observe, “Despite the largely disappointing findings from 50 years of cholesterol lower[ing] trials, the indictment and conviction of cholesterol as the causal agent in CVD [cardiovascular disease] has stood the test of time. … [Yet] the grand effort to reduce cholesterol as a strategy to improve health has failed.”