When you're scrambling up a rocky bluff or bounding along a riverbank, the last thing you want is gravel and grit seeping into your FiveFingers. The Vibram FiveFingers KSO is an all-new design with thin, abrasion-resistant stretch polyamide and breathable stretch mesh that wraps your entire forefoot to "Keep Stuff Out." A single hook-and-loop closure helps secure the fit. Non-marking Vibram TC1 performance rubber soles are razor-siped for a sure grip. KSO IS BEST FOR: Light Trekking, Climbing, Canyoneering, Running, Fitness Training, Martial Arts, Yoga, Pilates, Sailing, Boating, Kayaking, Canoeing, Surfing, Flats Fishing, Travel. Available in Black or Grey/Palm/Clay.
The WHO trial (so named because the international team of principal investigators contained World Health Organization members) tested the potential of clofibrate, a “pre-statin” cholesterol-lowering agent, to reduce heart attack morbidity and mortality. The investigators ultimately concluded that clofibrate "cannot be recommended as a lipid-lowering drug for community-wide primary prevention of ischaemic heart disease.” Nevertheless, clofibrate remained in use until 2002, when it was pulled for increasing cancer rates. In their review of studies such as the WHO trial, Uffe Ravnskov and David Diamond observe, “Despite the largely disappointing findings from 50 years of cholesterol lower[ing] trials, the indictment and conviction of cholesterol as the causal agent in CVD [cardiovascular disease] has stood the test of time. … [Yet] the grand effort to reduce cholesterol as a strategy to improve health has failed.”