I consider myself to be a pretty healthy eater. I’m gluten-free for health reasons, and I always try to make sure to eat a ton of vegetables. I make things from scratch, and am wary of overly processed foods. However, just like most of us, I can eat too much chocolate or indulge in something really carb-heavy and feel the after effects. For me, this means joint pain and the feeling of being hungover, along with many other equally fun symptoms.
The WHO trial (so named because the international team of principal investigators contained World Health Organization members) tested the potential of clofibrate, a “pre-statin” cholesterol-lowering agent, to reduce heart attack morbidity and mortality. The investigators ultimately concluded that clofibrate "cannot be recommended as a lipid-lowering drug for community-wide primary prevention of ischaemic heart disease.” Nevertheless, clofibrate remained in use until 2002, when it was pulled for increasing cancer rates. In their review of studies such as the WHO trial, Uffe Ravnskov and David Diamond observe, “Despite the largely disappointing findings from 50 years of cholesterol lower[ing] trials, the indictment and conviction of cholesterol as the causal agent in CVD [cardiovascular disease] has stood the test of time. … [Yet] the grand effort to reduce cholesterol as a strategy to improve health has failed.”