Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.
CrossFit, Inc. has been variously criticized and praised for its unorthodox approach to social media. This approach has included publishing articles and tweets about non-fitness topics (including politics, philosophy, and poetry) as well as directly interacting with other social media users and critics of the company's program.
Sweden's Staffan Lindeberg has a home page Paleolithic Diet in Medical Nutrition [archive.org]. A recent study of Staffan's has A Paleolithic diet improving glucose tolerance more than a Mediterranean-like diet in individuals with ischemic heart disease. Also see his first web page, an overview of his Kitava study: On the Benefits of Ancient Diets. Now he has a book Food and Western Disease: Health and nutrition from an evolutionary perspective. Here's a book review: Easy to Read, Informative, Packed with Footnotes on Studies.
Smoothies are generally discouraged on Whole30. However, if you must have one, choose a recipe with no added sweeteners and low-sugar fruits. This smoothie is more scoopable with a spoon, so you can slow down and savor it (important on Whole30!). The only sweet flavor comes from fresh raspberries — plus, this packs your bowl with fats from avocado and coconut milk.
Realistic Details: I think that this will be more challenging if your culinary experience is limited. A lot of people complain about the difficulty of the recipes. The fact is that if you can make eggs and broil or barbecue meat, or even if you can turn on an oven and toss a salad, you will be fine. You might be a little bored with the food if you are not savvy in the kitchen, but it might help if you are really a novice to get the cookbook in addition to the guide.
CrossFit gyms use equipment from multiple disciplines, including barbells, dumbbells, gymnastics rings, pull-up bars, jump ropes, kettlebells, medicine balls, plyo boxes, resistance bands, rowing machines, and various mats. CrossFit is focused on "constantly varied, high-intensity, functional movement," drawing on categories and exercises such as calisthenics, Olympic-style weightlifting, powerlifting, Strongman-type events, plyometrics, body weight exercises, indoor rowing, aerobic exercise, running, and swimming.
Fresh fruits, fresh vegetables, fresh meat—the paleo diet is all about eating foods straight from the Earth just as our ancestors did. Those ancestors didn't have livestock or crops to call their own, so Cordain advises to go with grass-fed and organic varieties whenever possible to limit exposure to pesticides, antibiotics, and other chemicals that didn't exist back then. Research from Emory University suggests that Paleolithic people obtained about 35% of their calories from fats, 35% from carbohydrates, and 30% from protein.
With a very simple shift we not only remove the foods that are at odds with our health (grains, legumes, and dairy) but we also increase our intake of vitamins, minerals, and antioxidants. Here is a great paper from Professor Loren Cordain exploring how to build a modern Paleo diet: The nutritional characteristics of a contemporary diet based upon Paleolithic food groups. This paper also offers significant insight as to the amounts and ratios of protein, carbohydrate and fat in the ancestral diet.
Cordain argues that chimpanzees and horses avoid meat, and they have big bellies that we would have if we didn’t ditch plants for meat. He also says meat increased human brain size, and decreased stomach size so we can have the six-pack abs that chimps can’t. But I looked at his endnotes with citations to research and couldn’t find the source for these theories. I also couldn’t find research showing that legumes and grains were invented by humans.
The Paleo Solution: The Original Human Diet by Robb Wolf, a research biochemist. Readers will understand digestion, how protein, carbohydrate and fat influence hormones, and how this plays into fat loss, health or disease. They'll understand the significance of dietary fats whether the concern is performance, health, longevity, or making your fanny look good in a bikini. The book goes into how lifestyle factors such as sleep and stress influence the hormone cortisol. It gets into basic blood work and what things people should ask their doctor to include to better assess inflammation and health. It also includes a detailed 30-day meal plan and a beginner exercise program. The exercise program is geared to the beginner or someone who is quite de-conditioned but the nutritional info would be helpful for anyone regardless of background. The author's website is Robb Wolf. He likes to pass out the information via weekly podcasts. Here's a video Introduction to the book. And here is an excerpt from the book: How to Keep Feces Out of Your Bloodstream (or Lose 10 Pounds in 14 Days). The many Amazon reviews all rave about the book. Published September 14, 2010.
Nourishing Traditions: The Cookbook that Challenges Politically Correct Nutrition and the Diet Dictocrat by Mary G. Enig, Ph.D. and Sally Fallon. The premise is the culinary traditions of our ancestors, and the food choices and preparation techniques of healthy nonindustrialized peoples, should serve as the model for contemporary eating habits. However, they push whole grains and dairy, which aren't Paleolithic.
On the surface, the Keto diet and the Paleo diet, two of the most popular diets out there, seem pretty similar. Both are low-carb plans that don't allow you to eat some of your favorite foods, such as cookies, pizza, and cereal. But there are actually some pretty important differences between the two diets that you should know, so you can figure out if either of them are right for you.
During this program there is no calorie counting, no measuring, and no weighing yourself for the entire 30 days. I know that can be hard — especially if you’re feeling totally bloated (which can happen in the beginning) or particularly svelte in the later weeks. Just don’t do it. Even though a lot of people’s weight begins to normalize during the 30 days, the program focuses a lot on the “non-scale victories,” as in how you’re feeling. Is your sleep better? How’s your skin? Do you feel like doing cartwheels with that extra energy? Cool.
Your only job during the Whole30 is to focus on making good food choices. You don’t need to weigh or measure, you don’t need to count calories, you don’t need to purchase everything organic, grass-fed, pastured, or local. Just figure out how to stick to the Whole30 rules in any setting, around every special circumstance, under any amount of stress… for 30 straight days. Your only job? Eat. Good. Food.
I often get caught up in focusing on numbers and scales, so I decided not to officially weigh myself before or after Whole30. But I can attest that everything about my body just felt better. I know saying something like "I lost eleven pounds" would sound much more convincing, but I could see that my stomach was slimmer, as was my face (which is awkwardly the first place I gain weight).
The data for Cordain's book only came from six contemporary hunter-gatherer groups, mainly living in marginal habitats. One of the studies was on the !Kung, whose diet was recorded for a single month, and one was on the Inuit. Due to these limitations, the book has been criticized as painting an incomplete picture of the diets of Paleolithic humans. It has been noted that the rationale for the diet does not adequately account for the fact that, due to the pressures of artificial selection, most modern domesticated plants and animals differ drastically from their Paleolithic ancestors; likewise, their nutritional profiles are very different from their ancient counterparts. For example, wild almonds produce potentially fatal levels of cyanide, but this trait has been bred out of domesticated varieties using artificial selection. Many vegetables, such as broccoli, did not exist in the Paleolithic period; broccoli, cabbage, cauliflower, and kale are modern cultivars of the ancient species Brassica oleracea.
When it comes to humans, we’re all just victims of our own biochemistry. Our brains are controlled and ruled by chemicals - from what we eat; to how and when we sleep; even to who we choose as a life partner. Biochemistry - or ‘biological chemistry’ - is concerned with all of the biochemical reactions which take place within our bodies and brains. This means that the simple act of eating a meal is actually composed of thousands of tiny...
According to the model from the evolutionary discordance hypothesis, "many chronic diseases and degenerative conditions evident in modern Western populations have arisen because of a mismatch between Stone Age genes and modern lifestyles." Advocates of the modern paleo diet have formed their dietary recommendations based on this hypothesis. They argue that modern humans should follow a diet that is nutritionally closer to that of their Paleolithic ancestors.
A great question to ask is “Does the Paleo diet work?” Here we have a head to head comparison between the Paleo diet and Mediterranean diet in insulin resistant Type 2 Diabetics. The results? The Paleo diet group REVERSED the signs and symptoms of insulin resistant, Type 2 diabetes. The Mediterranean diet showed little if any improvements. It is worth noting that the Mediterranean diet is generally held up by our government as “the diet to emulate” despite better alternatives. You can find an abstract and the complete paper here.
CrossFit, Inc. licenses the CrossFit name to gyms for an annual fee and certifies trainers. Besides the standard two-day "Level 1 Trainer Course", specialty seminars include gymnastics, Olympic weightlifting, powerlifting, strongman, running and endurance, rowing, kettlebells, mobility and recovery, CrossFit Kids, CrossFit Football, and self-defense and striking. Other specialized adaptations include programs for pregnant women, seniors, and military special operations candidates. Affiliates develop their own programming, pricing, and instructional methods. Many athletes and trainers see themselves as part of a contrarian, insurgent movement that questions conventional fitness wisdom. In addition to performing prescribed workouts, they follow CrossFit's nutrition recommendations, adopting a paleo and/or zone diet.