The Games include age-based divisions for younger and older competitors. Masters divisions were introduced at the 2010 Games. There are currently six divisions each for women and men: 35–39, 40–44, 45–49, 50–54, 55–59, and 60+. Divisions for teenagers were introduced in 2015: the age ranges are 14–15 and 16–17, for both boys and girls. Rather than regional events, masters and teen athletes qualify for the games by a second online competition following the Open. The top 200 athletes in each division worldwide are invited to compete in this qualifier, of which the top 20 (top 10 as of 2019) advance to the Games. Prior to the introduction of these secondary online qualifiers, masters and teens competitors qualified for the Games directly from the Open.
Food and Western Disease: Health and nutrition from an evolutionary perspective by Staffan Lindeberg (MD at Lund University in Sweden) is the newest book promoting the paleo diet. It covers the link between diet and disease in the Western world (all major diseases, including cancer, heart disease, obesity, stroke and dementia) and towards a greater knowledge of what can be defined as the optimal human diet. Benefits and risks are detailed. The Amazon reviews are all 5 stars. Especially read Susan Schenck's detailed review. You can read a preview at Google Books
The Primal Blueprint Cookbook: Primal, Low Carb, Paleo, Grain-Free, Dairy-Free and Gluten-Free by Mark Sisson and Jennifer Meier. Recipes include: Roasted Leg of Lamb with Herbs and Garlic, Salmon Chowder with Coconut Milk, Tomatoes Stuffed with Ground Bison and Eggs, and Baked Chocolate Custard. Recipes are simple and have limited ingredients. Complaints are the book is stuffed with unnecessary photos and proofreading could have been better, e.g. oven temperatures were left out. And recipes are not truly paleo. Despite what is on the cover dairy is used in some recipes. The Amazon reviews average to 4+ stars.
In 2011, the Games adopted an online qualification format, facilitating participation by athletes worldwide. During the five-week-long "CrossFit Open", one new workout is released each week. Athletes have several days to complete the workout and submit their scores online, with either a video or validation by a CrossFit affiliate. Since the Open is available to any level of athlete, many affiliates encourage member participation and the number of worldwide participants can be in the hundreds of thousands.
Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.