Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.
Odd programming – As you’ll read in another critique later in this article, I don’t agree with some of the workouts that are prescribed at some CrossFit gyms. For example, some workouts might call for high reps of snatches; these are an Olympic lift that require perfect form in order to be done successfully. Doing 30 reps of them is a sure-fire way to sacrifice form and dramatically increase the risk for injury.
The Great Cholesterol Con by Anthony Colpo. The definitive book on the non-dangers of dietary cholesterol and saturated fat was The Cholesterol Myths by Uffe Ravnskov, 2000. This book is six years newer. Its forward is by Uffe Ravnskov. To get a wonderful description of the book read the leading review at Amazon. The many reviews there average to 5 stars.
A metaresearch group at Tilburg University in the Netherlands investigates scientists’ research methods and operations, scrutinizing questionable practices such as selective reporting of statistical tests and data massaging. The group instead advocates for practices such as preregistering studies and making experimental data immediately available for open external review and verification. Its members are optimistic that “the perverse incentives of careerist academia, to hoard data and sacrifice rigor for headline-generating findings, will ultimately be fixed.”