Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.
I LOVE Whole30. I preach it and I live it. The reason I am only posting 3 stars is because I am really disappointed in this cookbook, which I anticipated for months. I love crockpot meals and soups, and this didn't hardly have anything like that. Most of these meals did not look very appetizing. I don't want to have to purchase odd ingredients for that 1 meal and you'll be doing that with every one of these recipes. I hope they come out with another cookbook that focuses more on altering the more common meals that we are comfortable with.
You're not tracking calories. You won't feel hungry. You won't be eating based on a points system. You're going to miss your morning doughnuts, but this isn't like any diet you might be used to. Whole30 co-founder Melissa Hartwig actually doesn't like calling the Whole30 a "diet" at all. “Most diets are spent white-knuckling your way through deprivation, restriction, hunger, tuning out your body’s signals, and obsessing over tracking and weighing your food,” Hartwig says. She doesn't think that type of behavior is sustainable, and if you've ever tried dieting, you probably agree.
This 2003 CrossFit Journal article captures an early conception of a universal, multi-event test of fitness that laid the foundation for CrossFit competition, including what would become the CrossFit Open and the CrossFit Games. The design requirements for such a test "included but were not limited to the following: quantifiable results; consistency with the CrossFit fitness concept; raising our commitment to improving absolute strength, relative strength, and gymnastic foundations; balancing intrinsic abilities of smaller and larger athletes; emphasizing exercises critical to and foundational to advanced training; mixing training demands within each test and, of course, over the total competition; a design that would identify an athlete’s weaknesses and possibly stand as a workout plan for improving overall fitness; and, finally, we wanted to design a competition that would be 'hard as hell.'"