Workout 2 Part A begins with the dumbbells on the floor and the athlete standing behind their dumbbells. At the start of the ascending 20min clock, the athlete may pick up their dumbbells and begin the workout. Upon completion of the first set of deadlifts, the athlete will move to the burpee box over. Athletes may take as many sets, breaking up the work as needed, to complete the required number of repetitions throughout the workout.
Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.
A metaresearch group at Tilburg University in the Netherlands investigates scientists’ research methods and operations, scrutinizing questionable practices such as selective reporting of statistical tests and data massaging. The group instead advocates for practices such as preregistering studies and making experimental data immediately available for open external review and verification. Its members are optimistic that “the perverse incentives of careerist academia, to hoard data and sacrifice rigor for headline-generating findings, will ultimately be fixed.”