Paleonutrition by Mark Q. Sutton, Kristin D. Sobolik, and Jill K. Gardner is the analysis of prehistoric human diets and the interpretation of dietary intake in relation to health and nutrition. This is a substantial text that combines background to paleonutrition, an extensive bibliography, a discussion on methods, and case studies. Published February 23, 2010.
Glassman reigns over this rampantly growing horde like a tribal chieftain. He now owns 100 percent of CrossFit and answers to no board of directors. Cash tends to race through the company. Until recently, the Glassmans each drew a salary of $750,000 a year; the travel and entertainment budget is in the tens of millions of dollars, and Glassman also spends money on what he calls "brand statements," including a set of $15,000 single-speed Swiss bikes and a $350,000, 1,500-horsepower fully customized 2011 Camaro convertible. (Before our visit to El Borracho, I followed him to a meeting to see about another "brand statement": custom luggage for his senior team, emblazoned with Uncle Pukie.)
The Paleo Diet: Eating like your ancestors doesn't guarantee you'll lose weight. While the diet emphasizes plenty of foods that are good for weight loss, such as lean protein and fruits and vegetables, you would still need to eat fewer calories to drop a few pounds. So if you're binging on nuts and fruit, you could actually gain weight on the Paleo Diet.
The data for Cordain's book only came from six contemporary hunter-gatherer groups, mainly living in marginal habitats. One of the studies was on the !Kung, whose diet was recorded for a single month, and one was on the Inuit. Due to these limitations, the book has been criticized as painting an incomplete picture of the diets of Paleolithic humans. It has been noted that the rationale for the diet does not adequately account for the fact that, due to the pressures of artificial selection, most modern domesticated plants and animals differ drastically from their Paleolithic ancestors; likewise, their nutritional profiles are very different from their ancient counterparts. For example, wild almonds produce potentially fatal levels of cyanide, but this trait has been bred out of domesticated varieties using artificial selection. Many vegetables, such as broccoli, did not exist in the Paleolithic period; broccoli, cabbage, cauliflower, and kale are modern cultivars of the ancient species Brassica oleracea.
Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.