Two friends and I discussed the article, and then one proposed something unbelievable: "We should do Whole30 together." After considering what Philipps' had to say about it, I decided to give it a try. Then Health editor in chief Lori Leibovich asked me to document my Whole30 experience with daily video diaries on Health Instagram stories, and I knew there was no turning back. I was about to do my first diet ever.
At CrossFit Panther City, we believe in a commitment to excellence. We expect excellence in our coaches and we expect a full commitment from our members. When you make the decision to join us in your fitness journey we, in turn, commit ourselves to working just as hard to help you meet your goals. We just ask one thing: show up and give everything you have that given day. We all have days of feeling tired, worn out after a long week, or just downright lazy. Come anyway. You won’t regret it. If you show up and work hard we can assure you that you will get fitter, faster, stronger. That’s our guarantee to you.
As someone who isn't a "sweets person," I was surprised at how much I craved sugar during my first Whole30 — until I started reading condiment labels. "So much of our food is filled with sugar and unknown chemicals and substances, and it falls on each person to find out what is in the food and make an informed decision on whether or not they want to consume those substances," says Cohn. "Read all food labels and ingredient labels, and look up any of the ingredients on a label that you have not heard of to find out what it is."
This book has simply changed my life. I know that you aren't supposed to weigh yourself on this program, but weighing myself is a motivator so I decided to skip that rule. It's only been two weeks and already I feel so much better. I am more alert in the mornings and my acid reflex is gone. In addition, my migraines seemed to have disappeared entirely. What is really motivating me is the fact that I lost 15 pounds and 10 overall inches in two weeks. I also love the fact that I have the energy to exercise again. I look forward to continuing this program even after my 30 days are up. I just feel that healthy and energetic! I'll post an update once my 30 days are complete. :)

The China Study is frequently cited when criticizing the Paleo Diet – focusing on a vegetarian diet and consuming rice is healthier than the Paleo Diet. I respectfully disagree with the conclusions drawn from that book but that’s awesome if you want to go plant-based! [7], and will leave you to make your own conclusions based on your own self-experimentation.


In July 2016, a New York Times article on use of Instagram by dieters noted that participants in the Whole30 program had shared over one million Instagram posts using the #Whole30 hashtag, and noted that those sharing the tag were "one of seemingly endless like-minded communities," comparing it with the over 3.5 million posts under the #WeightWatchers hashtag.[11]
As with paleo, doing keto for more than a few weeks could lead to nutrient deficiencies according to Andy Yurechko, MS, RD, of Augusta University Medical Center in Georgia . He says lack of fiber is the biggest concern for keto fanatics, who may experience constipation. But it's possible to get fiber by eating lower-carb vegetables like broccoli and chia seeds.
The Paleo diet includes nutrient-dense whole fresh foods and encourages participants to steer away from highly processed foods containing added salt, sugar, and unhealthy fats. However, the omission of whole grains, dairy, and legumes could lead to suboptimal intake of important nutrients. The restrictive nature of the diet may also make it difficult for people to adhere to such a diet in the long run.  More high-quality studies including randomized controlled trials with follow-up of greater than one year that compare the Paleo diet with other weight-reducing diets are needed to show a direct health benefit of the Paleo diet. Strong recommendations for the Paleo diet for weight loss cannot be made at this time.
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The data for Cordain's book only came from six contemporary hunter-gatherer groups, mainly living in marginal habitats.[36] One of the studies was on the !Kung, whose diet was recorded for a single month, and one was on the Inuit.[36][37][38] Due to these limitations, the book has been criticized as painting an incomplete picture of the diets of Paleolithic humans.[36] It has been noted that the rationale for the diet does not adequately account for the fact that, due to the pressures of artificial selection, most modern domesticated plants and animals differ drastically from their Paleolithic ancestors; likewise, their nutritional profiles are very different from their ancient counterparts. For example, wild almonds produce potentially fatal levels of cyanide, but this trait has been bred out of domesticated varieties using artificial selection. Many vegetables, such as broccoli, did not exist in the Paleolithic period; broccoli, cabbage, cauliflower, and kale are modern cultivars of the ancient species Brassica oleracea.[28]
According to the model from the evolutionary discordance hypothesis, "many chronic diseases and degenerative conditions evident in modern Western populations have arisen because of a mismatch between Stone Age genes and modern lifestyles."[25] Advocates of the modern paleo diet have formed their dietary recommendations based on this hypothesis. They argue that modern humans should follow a diet that is nutritionally closer to that of their Paleolithic ancestors.
Fattening cattle with corn changes the lipid balance and is clearly not the natural diet for a grass eating cow. In Simple change in cattle diets could cut E. coli infection researchers have found that when cattle were fed hay or grass for just five days before slaughter, much less E. Coli cells were present in the animal's feces and virtually all surviving E. coli bacteria were not acid-resistant and were killed by human stomach acid.

We also talked about our meals, our struggles, and the results we were seeing from Whole30. Mentally, I felt more clear-headed and emotionally stable. I slept deeper and remembered more of my dreams, something that tends to never happen. (In one dream, I accidentally ate a slice of pizza and cried about it because if you break your Whole30 diet, you're supposed to start again from Day 1.)

I experienced some funky physical symptoms during the first 10 days or so, but this is pretty typical of a Whole30. I would feel great, and then the next day I would feel tired, achy, and bloated. Depending on what your diet was like before you started the Whole30, you’re bound to get hit by some sort of detoxing symptoms. If you’re doing this after eating a lot of sugar and processed food, your symptoms might be a bit more severe. However, the book assures you it’s normal, and it will even out. According to the authors, the bacteria in your gut are shifting and creating a new landscape. Your body is getting used to this new diet of protein and a ton of veggies with the absence of sugar. Things adjust and shift. For me, this meant a couple days of feeling off.


"Loren Cordain's extensive research demonstrates how modern westernized diets drastically depart from the original diet humans consumed for millions of years. In The Paleo Diet and The Paleo Diet Cookbook, Dr. Cordain shows how diets high in grains, dairy, vegetable oils, salt, and refined sugars are at odds with our genetic legacy and then shares his uncomplicated strategy for losing weight and getting healthy."
The Great Cholesterol Con by Anthony Colpo. The definitive book on the non-dangers of dietary cholesterol and saturated fat was The Cholesterol Myths by Uffe Ravnskov, 2000. This book is six years newer. Its forward is by Uffe Ravnskov. To get a wonderful description of the book read the leading review at Amazon. The many reviews there average to 5 stars.
Thank you CFA coaches for always scaling the WOD for my medical needs, but still making the WOD fun and challenging. I may not be able to lift heavy or ever be a part of the CF games, but I do feel like a part of CFA family and with that I could never go back to a gym. It’s been a privilege meeting and working out with great people. I feel honored to be selected CFA Athlete of the Month. CROSSFIT PROUD!!!

Sport-specific athletes – Like the specialists, if you are an athlete training for a sport, you’d be better off finding a coach that is trained in getting great performances out of athletes in your specific sport. Every sport has special movements that require certain types of power in specific muscles. CrossFit prepares you for everything, but won’t improve your specific sport skills unless you are training for those specific sport skills! Many athletes choose to combine CrossFit with sport-specific workouts (see things like CrossFit Football) in their off-season for conditioning, but that’s up to each sport’s coach.

An Interview with Ward Nicholson now has three parts on the web. Good overview of man's diet over the past 65 million years. Long but highly recommended reading. First published in Chet Day's "Health & Beyond" newsletter. Now part of a very comprehensive Beyond Vegetarianism site. Every argument that your vegetarian friends use to avoid meat for health reasons is debunked here.

Exercise is a vital part of the live-by-your-genetic-code equation. Surviving in the Stone Age meant a constant on-the-go lifestyle that probably required 4,000-plus calories a day, according to David L. Katz, MD, director of the Yale University Prevention Research Center. Even most people who hit the gym regularly won't need to eat that many calories, but the principle of using food as fuel to exercise still stands.
You start to talk a language nobody understands – talking to a CrossFitter is like talking to somebody in a foreign language. CrossFit people oftentimes forget that nobody outside of CF understands what half the stuff they say means, so they shout out achievements or accomplishments and explain how quickly they did specific exercises…but they don’t realize nobody really cares!
Can a vegan diet help you lose weight? People become vegan for a variety of reasons, from animal welfare and sustainability to improved heart health or weight loss. Learn how a vegan diet may help people lose extra weight and maintain a healthy weight long-term. We also look at the best foods to try and tips to make the transition to a vegan diet easier. Read now
With a very simple shift we not only remove the foods that are at odds with our health (grains, legumes, and dairy) but we also increase our intake of vitamins, minerals, and antioxidants. Here is a great paper from Professor Loren Cordain exploring how to build a modern Paleo diet: The nutritional characteristics of a contemporary diet based upon Paleolithic food groups. This paper also offers significant insight as to the amounts and ratios of protein, carbohydrate and fat in the ancestral diet.
So, with my sister-in-law as my Whole30 guide, I successfully followed the program for the entire month of November. The beginning was really bumpy for me — I am truly an emotional eater and I am absolutely addicted to sugar. But once it was done, it was clear to me that the benefits outweighed the challenges. I now have a whole new understanding and respect for my body and a newfound control over the food I put in my mouth. Full disclosure that the Whole30 diet affects everyone differently, but here are the seven biggest changes I saw in myself after 30 days:
But critics argue that the unlimited amount of red meat the paleo diet allows may have an adverse effect on heart health in people with diabetes, as research links eating red meat in excess to poor heart health. (11)  If you have diabetes and don’t moderate your red-meat intake, this could be a big problem, as people with diabetes are 2 times as likely to die of heart disease as people who do not have diabetes. (12)
In my first CrossFit experience three years ago, I almost made myself puke because I wanted so badly to finish with a good time. Last year, I did another CrossFit workout that I hadn’t properly prepared for and cranked out 100 pull ups quickly…and I ended up walking around with T-rex arms for a WEEK because I physically could not straighten them. Not kidding.
I’m so excited to have stumbled across your blog and your meal plans. I’ve been wanting to do the whole 30 for a while, but as a busy Mom and dayhome provider I didn’t want to put even more time and effort into increasing recipe sizes and altering grocery lists to accommodate more than one person. Since you’ve done the work for me for a family of 5 I can’t make any more excuses!
These are great! Thanks. I was wondering what your budget is for all this food. I seem to spend much more money for groceries when we are on whole 30. I try to shop at Costco and discount stores as I can, but it still seems like a lot. My shopping list I created for week one on my previous w30 was like $350 for a family of 5 (including food for one vegan). Is this normal?

No background science here or lengthy explanations, only 15 easy guidelines to follow to kick-start your Paleo journey. It’s up to you to decide to what extent you want to follow those guidelines, but if you follow them 100% you can be assured that you are eating the best food for your body and greatly investing in your long term health and well-being.
You’ll be exposed to a ton of new, delicious recipes. If you know you’re not the cooking type, start simple. Instead of making the fancy egg-bake in a cast-iron pan, grab some eggs, veggies, sausage, and avocado then scramble your breakfast. Top it with (sugar-free) hot sauce, and you'll have yourself a solid meal in seven minutes. Don't be afraid to make that for breakfast five times a week; making similar meals over and over again is easier than trying to whip up (new) complicated ones.
During this program there is no calorie counting, no measuring, and no weighing yourself for the entire 30 days. I know that can be hard — especially if you’re feeling totally bloated (which can happen in the beginning) or particularly svelte in the later weeks. Just don’t do it. Even though a lot of people’s weight begins to normalize during the 30 days, the program focuses a lot on the “non-scale victories,” as in how you’re feeling. Is your sleep better? How’s your skin? Do you feel like doing cartwheels with that extra energy? Cool.
The line of VivoBarefoot shoes have a design based on the simple principle that being barefoot is the healthiest way for you and your feet to be. An ultra thin (3mm) puncture resistant sole allows your feet to be as millions of years of evolutionary design intended Barefoot! There are many styles with each in many colors. Plus many more styles that are not available through Amazon.com. Many of them are conventionally styled and can be worn to work. For the current models see Amazon.com. One style is discussed below.
One of the most interesting experiments comes after you finish Whole30 and slowly start adding foods back into your diet. You get to test how foods you stopped eating during the month affected you after you added them back in. The most shocking for me? Legumes make me feel bloated (they just do!). When I added gluten back, the next day I broke out in a rash. And now that I've curbed my "sugar dragon" (that's what they call sugar cravings on Whole30), I try to avoid sugar as much as humanly possible. In fact, December came after my Whole30 experience, so of course I indulged in a few glasses of wine at a holiday party, and BOOM — my skin broke out. Now I have a better idea of what to avoid altogether, and what to watch if I do decide to indulge.
Glassman is proud of his role in all this, but the system puts him and CrossFit at a very real risk. As the world of CrossFit grows, as more businesses enter and profit, and his share of it becomes smaller, CrossFit's greatest success--gaining mainstream acceptance as exercise and a sport--could turn it generic, like baseball or skiing. "One of our greatest fears is becoming escalator," says Dale Saran, CrossFit's general counsel, referring to what was once a trademarked name brand of Otis Elevator. So, although Glassman keeps the CrossFit business model radically loose and open, he protects the brand name with an iron fist.
A program fit and scale-able to anyone who decides to make the commitment to be better.  We utilize compound movements through body-weight, weightlifting and conditioning elements, at varying times of duration and intensity.  The result, a fully capable and efficient athlete that is ready to take on any task life or athletics throws at it and a body that looks the part.
It was within this context that Glassman began ramping up his affiliation program. This was growth without a safety net: Anyone who passed his two-day seminar could apply to open a box, call it CrossFit, and then rush paying customers through squats and snatches or whatever crazy WOD they dreamed up. To Glassman, himself a passionate libertarian, this was the right thing to do: He wants his affiliates to be free to open up a box in a garage or a warehouse or wherever else, and train how they want, and charge what they want. They should have the opportunity he had. He detests supposed experts who say their certification or education makes them better than him or his people. At the end of the day, he believes, the free market will provide all the necessary quality control.
But listen--we'd both been relatively inactive for years and each about 25 pounds overweight. Between the two of us we lost 34 lbs in 30 days and we are still going to keep up a serious commitment to Whole 30, with a few supplemental treats now and then. We feel better, we have new confidence about getting dressed in the morning, and we're more fit than in years, mostly because we have the energy to do more. The amazing thing is that you will NOT feel hungry if you hang in there and consistently prepare foods as per the cookbook/menus. There is also a very supportive and helpful forum online to supplement the book.

There are about half a dozen diets that are very similar. They all recommend you eat "meat and veg" The reason Whole 30 works for me is because you can have potatoes and fruit. An example of a whole 30 meal would be: 2 pork chops, mashed potatoes made with chicken stock, green beans, finish with your choice of fruit. My favorite is a few grapes or pineapple chunks. Also the goal it to make it 30 days without cheating. There have been several times I would think: OK I can't cheat now I only have __ more days to go. Having an end in site helped me. When I started adding back in food groups after the 30 days. I figured out that I do not do well with Dairy. Now the only dairy I use is real butter. I never thought I could live without cheese... But now I don't think it's a good idea for me. So it helps you figure out what you can and can not eat and still feel good.


Eat WELL Feel GOOD: Practical Paleo Living by Diane Frampton has over 200 recipes that makes paleo eating simple, delicious, and ultimately, intuitive. So they claim. There are only a few reviews at Amazon. They all like the book, but their lack of details makes it appear that they are not truly independent reviews. The recipes have a Crossfit appeal to them. Chef Rachel Albert has made some of the recipes and posted here [archive.org].
We don’t follow fads, trends or other “fitness and health” gimmicks. What we do is not easy, it’s hard, but it produces results! We build strength as the primary outcome of our training. Using the squat, press, deadlift, bench press and other lifts, we build functional strength. Once clients have a strength foundation, they can expand their fitness into other areas for life, recreation of sport using conditioning and skill work.
These are great! Thanks. I was wondering what your budget is for all this food. I seem to spend much more money for groceries when we are on whole 30. I try to shop at Costco and discount stores as I can, but it still seems like a lot. My shopping list I created for week one on my previous w30 was like $350 for a family of 5 (including food for one vegan). Is this normal?

Paleo critics point out that not all grains are created equal—whole grains do not spike your blood sugar as much as refined grains. Even so, paleo dieters still steer clear of grains because they contain different compounds and proteins like gluten, lectins and phytates, which they claim cause inflammation in the body and block other nutrients from being absorbed. Paleo critics say these compounds are not a problem unless you have an allergy or sensitivity.
Eat generous amounts of saturated fats like coconut oil and butter or clarified butter. Beef tallow, lard and duck fat are also good, but only if they come from healthy and well-treated animals. Beef or lamb tallow is a better choice than lamb or duck fat. Olive, avocado and macadamia oil are also good fats to use in salads and to drizzle over food, but not for cooking. For more information, have a look at our beginner’s guide to Paleo and fat.
What is the Stone Age or Paleo diet? The Stone Age diet, or paleolithic diet, is based on the foods early humans would have eaten in the Stone Age. It may help in weight loss. Supporters argue that, since our genes have changed little in millions of years, items such as meat, herbs, and insects are more suitable foods for humans than grains and flours. Read now
"Every fad diet thinks it has discovered the root of all evil," says Dr. Ochner. But nutrients in legumes, whole grains, and dairy—all of which are forbidden on the paleo diet—can help to lower the risk of osteoporosis and cardiovascular disease, reduce blood pressure, and promote a healthy weight, he says. Cutting dairy, the primary source of calcium and vitamin D in modern diets, is especially worrisome for women who want to avoid osteoporosis.
Using a 1/2 cup measuring cup, scoop the potatoes out of the skillet and into the greased jumbo muffin cups. Depending on the size of your potato, you may get slightly more or less than 5 cups. Using a small jar or cup, press an indentation into the potatoes, creating a well in the middle and pushing the potatoes up the sides of the muffin cup. This is your nest.

The Great Cholesterol Con: The Truth About What Really Causes Heart Disease and How to Avoid It by Dr. Malcolm Kendrick reveals that high cholesterol levels do not cause heart disease; that high-fat diets–saturated or otherwise–do not affect blood cholesterol levels; and that for most men and all women the benefits offered by statins are negligible at best. Other data is also provided that shows that statins have many more side affects than is often acknowledged.

We have been lied to all our lives and told to eat plenty of whole grains and low fat. Grains have been genetically modified for so long and its effects on the human body have never been tested. Following the Paleo Diet principles have changed my life and helped me lose 37 pounds effortlessly. My health has vastly improved and I no longer have uncontrollable junk food cravings. I didn't know the cravings could be stopped, I just assumed I had no will power. My Doctor recommended this diet and I can't thank him enough! If you follow this way of living you will never regret it so buy this book and improve you health now!


It’s easy to find more guidance online, but a book also makes a handy reference. "The Paleo Diet," for example, outlines basic Paleo principles and offers three “levels” that allow for different degrees of cheating – three “open meals” per week on the “entry level” plan, two on “maintenance” and just one on “maximal.” Depending on the level, you might also get “transitional” condiments (low-fat dressing and salsa) and drinks (coffee, beer or wine in moderation) to wash down the meat and plants. You can use the levels as you like. Start with the first and move gradually to the more restrictive – or just stay put. For more dramatic changes, head right to the third.
You’ll stay pretty full on the Paleo diet. Nutrition experts emphasize the importance of satiety, the satisfied feeling that you’ve had enough. You shouldn’t feel hungry on this diet – protein and fiber are filling, and you’ll get plenty of both. One small study of 29 participants published in Nutrition & Metabolism in 2010 found Paleo dieters felt just as full but consumed fewer calories than their Mediterranean counterparts.
Do not step on the scale or take any body measurements for 30 days. The Whole30 is about so much more than weight loss, and to focus only on body composition means you’ll overlook all of the other dramatic, lifelong benefits this plan has to offer. So, no weighing yourself, analyzing body fat, or taking comparative measurements during your Whole30. (We do encourage you to weigh yourself before and after, so you can see one of the more tangible results of your efforts when your program is over.)
You likely will lose weight on Whole30—“many people do appear to lose weight while following the plan, likely due to the decreased reliance on processed foods and increased consumption of whole foods, such as fruits and vegetables,” says Cohen. But it wasn’t designed for weight loss, and once the 30 days are over, you may gain all the weight back as you reintroduce your body to a normal diet.
Workout 2 Part A begins with the dumbbells on the floor and the athlete standing behind their dumbbells. At the start of the ascending 20min clock, the athlete may pick up their dumbbells and begin the workout. Upon completion of the first set of deadlifts, the athlete will move to the burpee box over. Athletes may take as many sets, breaking up the work as needed, to complete the required number of repetitions throughout the workout.
Gluten is a protein found in things like rye, wheat, and barley. It’s now being said that much of our population may be gluten-intolerant (hence all the new “gluten-free!” items popping up everywhere). Over time, those who are gluten intolerant can develop a dismal array of medical conditions from consuming gluten: dermatitis, joint pain, reproductive problems, acid reflux, and more.[2]

CrossFit NYC was the sixteenth (of now over ten thousand) CrossFit affiliates. We were the first in New York (2005). Our coaching staff is the largest and most experienced of any CrossFit affiliate in the world. We have supervised over 75,000 CrossFit classes totaling nearly 1 million workouts. Our members include professional athletes and dancers, desk jockeys and stay-at-home moms, celebrities and grandparents. If you live in New York and you want to get in the best shape of your life, CrossFit NYC is the place to be.
Paleo diets are based on a simple premise – if the cavemen didn’t eat it, you shouldn’t either. So long to refined sugar, dairy, legumes and grains (this is pre-agricultural revolution), and hello to meat, fish, poultry, fruits and veggies. The idea is that by eliminating modern-era foods like highly-processed carbs and dairy, you can avoid or control “diseases of civilization” like Type 2 diabetes and heart disease, and likely lose weight too. What you eat and how much depend on your goals or the specific program you’re on, if you choose to follow one. The high-protein diet is ranked poorly among U.S. News experts, who consider it too restrictive to be healthy or sustainable.
The Whole30 book is the perfect thing to read while you’re visiting your in-laws or don’t feel like telling Aunt Sue for the 100th time what you do for a living. It’s helpful, it’s clear, and it will get you motivated. Want even more Whole30 recipes? Hartwig's latest Whole30 Cookbook may not have the nitty-gritty plan details, but the recipes are baller.
Evolution of the Human Diet: The Known, the Unknown, and the Unknowable by Peter S. Ungar. Diet is key to understanding the ecology and evolution of our distant ancestors and their kin, the early hominins. A study of the range of foods eaten by our progenitors underscores just how unhealthy many of our diets are today. This volume brings together authorities from disparate fields to offer new insights into the diets of our ancestors. Paleontologists, archaeologists, primatologists, nutritionists and other researchers all contribute pieces to the puzzle. The book has four sections: Reconstructed diets based on hominin fossils--tooth size, shape, structure, wear, and chemistry, mandibular biomechanics. Archaeological evidence of subsistence--stone tools and modified bones. Models of early hominin diets based on the diets of living primates--both human and non-human, paleoecology, and energetics. Nutritional analyses and their implications for evolutionary medicine.

“Hartwig, a sports nutritionist and cocreator of the Whole30 diet plan, packs her fourth book on the subject with 150 recipes that are, as the cover proclaims in all-caps, “totally compliant.” That means heavy emphasis on eggs, meat, fish, and fresh vegetables, but no grains, dairy, legumes or added sugars. Whether or not one buys into Whole30, there is no denying that Hartwig has come up with a clever array of healthy and flavorful dishes. Highlights include Asian beef zoodle (zucchini noodles) soup, which is similar to Vietnamese pho but uses zucchini noodles, and grilled Jamaican jerk salmon with fresh mango salsa. Many of the recipes come courtesy of guest cooks from various food blogs. For instance, Michelle Smith, from the Whole Smiths blog, contributes cherry-chipotle BBQ chicken thighs, with the fruit providing the sweetness and ground chipotle bringing the heat. Veteran food and cocktail photographer Brent Herrig drives home the point that a burger served on a tomato slice is as delectable as one on a bun, and that meatballs do just fine in a cream sauce made with coconut milk. (Dec.)” —Publishers Weekly

Another 2014 study in the European Journal of Clinical Nutrition compared the effects of the Paleo plan to those of a standard low-fat diet on 70 obese, postmenopausal women. After six months, the Paleo group lost 14 pounds on average, while the other group lost nearly 6 pounds. After a year, the Paleo group had lost 19 pounds on average, and the low-fat dieters had dropped 10 pounds. A year later, both groups had regained some weight: The Paleo group was still down 10 pounds, while the low-fat group had dropped an average of more than 6 pounds.
2) There is a big step up in the use of tree nuts in the cookbook. I never really got why tree nuts would be included in an anti-inflammatory diet when they are one of the more common allergens. Aside from that, I'm super allergic to tree nuts (need an epi-pen) so this was, personally, lame for me. Nuts were easy to avoid in 30 Day Guide but many more recipes include them in the cookbook.
The WHO trial (so named because the international team of principal investigators contained World Health Organization members) tested the potential of clofibrate, a “pre-statin” cholesterol-lowering agent, to reduce heart attack morbidity and mortality. The investigators ultimately concluded that clofibrate "cannot be recommended as a lipid-lowering drug for community-wide primary prevention of ischaemic heart disease.” Nevertheless, clofibrate remained in use until 2002, when it was pulled for increasing cancer rates. In their review of studies such as the WHO trial, Uffe Ravnskov and David Diamond observe, “Despite the largely disappointing findings from 50 years of cholesterol lower[ing] trials, the indictment and conviction of cholesterol as the causal agent in CVD [cardiovascular disease] has stood the test of time. … [Yet] the grand effort to reduce cholesterol as a strategy to improve health has failed.”
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