Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.

No background science here or lengthy explanations, only 15 easy guidelines to follow to kick-start your Paleo journey. It’s up to you to decide to what extent you want to follow those guidelines, but if you follow them 100% you can be assured that you are eating the best food for your body and greatly investing in your long term health and well-being.
People looking for support and community – This is the appeal to CrossFit for me: every CrossFit gym has a really tight-knit community feel to it. You’re not just a membership payment to them; you’re a person that needs support. When Nerd Fitness gyms start popping up (don’t think it won’t happen!), I’ll be drawing a lot of inspiration from CF as to how members are so supportive and inclusive of each other.

Exercise is a vital part of the live-by-your-genetic-code equation. Surviving in the Stone Age meant a constant on-the-go lifestyle that probably required 4,000-plus calories a day, according to David L. Katz, MD, director of the Yale University Prevention Research Center. Even most people who hit the gym regularly won't need to eat that many calories, but the principle of using food as fuel to exercise still stands.
In 1995, as Glassman was burning the last of his bridges at local gyms, he got a call from a friend who worked at the sheriff's department in Santa Cruz. The department had heard about him and wanted him to train officers. Glassman, who was in the middle of a breakup with a longtime girlfriend, decided to go. He set up shop in a health center called Spa Fitness and taught his own brand of fitness training, which he had begun calling CrossFit, to officers and anyone else looking to buy 60 minutes of sweat.

Food and Western Disease: Health and nutrition from an evolutionary perspective by Staffan Lindeberg (MD at Lund University in Sweden) is the newest book promoting the paleo diet. It covers the link between diet and disease in the Western world (all major diseases, including cancer, heart disease, obesity, stroke and dementia) and towards a greater knowledge of what can be defined as the optimal human diet. Benefits and risks are detailed. The Amazon reviews are all 5 stars. Especially read Susan Schenck's detailed review. You can read a preview at Google Books
Vitamin D is the one supplement that would be paleo. At least it would be for those of us that don't live outside year round. You can have your D level measured. The low RDAs only prevent definable deficiences, not problems that take a long time to develop. Michael Holick, MD is a leading writer on this subject. This is a 10 page PDF: Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis and its companion Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease [change PDF to 100% to read]. Or if you prefer, there is an hour video on YouTube.

Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back to Health by William Davis, MD. A renowned cardiologist explains how eliminating wheat from our diets can prevent fat storage, shrink unsightly "wheat belly" bulges, and reverse myriad health problems, like minor rashes and high blood sugar. The author contends that every single human will experience health improvement by giving up modern wheat. The book provides readers with a user-friendly, step-by-step plan to navigate a new, wheat-free lifestyle. Informed by cutting-edge science and nutrition, along with case studies from men and women who have experienced life-changing transformations in their health after waving goodbye to wheat. The author's blog. Published August 30, 2011.
Glassman is proud of his role in all this, but the system puts him and CrossFit at a very real risk. As the world of CrossFit grows, as more businesses enter and profit, and his share of it becomes smaller, CrossFit's greatest success--gaining mainstream acceptance as exercise and a sport--could turn it generic, like baseball or skiing. "One of our greatest fears is becoming escalator," says Dale Saran, CrossFit's general counsel, referring to what was once a trademarked name brand of Otis Elevator. So, although Glassman keeps the CrossFit business model radically loose and open, he protects the brand name with an iron fist.
[…] I don't like the word "diet", so I'll say that this is more a way of changing what you eat long-term. It's all based around what our ancestor hunter-gatherers would have eaten, and what we've evolved to be able to process and absorb. The very basic level of it, is that you don't eat carbohydrates, processed meats or sugars, and cut out dairy products. You instead eat plenty of fresh meat, fish, vegetables, fruits and nuts. You can still have oil, provided it's natural – so coconut, peanut & olive oil are all good. The good thing is that you're also allowed to take this to your own level – so if you want a couple of days off a week – say, weekends, you can do it & it will still be a lot healthier for you. This is a really helpful site I've used to make a note on my shopping list of what's allowed: The Ultimate Paleo Diet Food List | Ultimate Paleo Guide […]
While gorging on cheese and bread post–Whole30 sounds fun, it's not the way you're supposed to end the elimination diet. Instead, you want to slowly reintroduce certain food groups to see how each individually affects your body and mind. I decided to go this route because I was interested in discovering food sensitivities. And frankly, I was afraid of puking the second I came into contact with dairy or alcohol.
There are about half a dozen diets that are very similar. They all recommend you eat "meat and veg" The reason Whole 30 works for me is because you can have potatoes and fruit. An example of a whole 30 meal would be: 2 pork chops, mashed potatoes made with chicken stock, green beans, finish with your choice of fruit. My favorite is a few grapes or pineapple chunks. Also the goal it to make it 30 days without cheating. There have been several times I would think: OK I can't cheat now I only have __ more days to go. Having an end in site helped me. When I started adding back in food groups after the 30 days. I figured out that I do not do well with Dairy. Now the only dairy I use is real butter. I never thought I could live without cheese... But now I don't think it's a good idea for me. So it helps you figure out what you can and can not eat and still feel good.
Whole30 is about a physiological and psychological reset (so, not just about the number on the scale), and if you’re looking to jumpstart your system and make healthier food choices, the 30-day plan may be a good guide for you. “It’s really for someone who is looking to make drastic changes for a short period of time and understands this is a band-aid, not a cure all,” says Zeitlin.

The Paleo diet, also referred to as the caveman or Stone-Age diet, includes lean meats, fish, fruits, vegetables, nuts, and seeds. Proponents of the diet emphasize choosing low-glycemic fruits and vegetables. There is debate about several aspects of the Paleo diet: what foods actually existed at the time, the variation in diets depending on region (e.g., tropical vs. Arctic), how modern-day fruits and vegetables bear little resemblance to prehistoric wild versions, and disagreement among Paleo diet enthusiasts on what is included/excluded from the diet. Because of these differences, there is not one “true” Paleo diet.
1) During a CrossFit workout, you’re often told to complete a number of strength training or endurance exercises as fast as possible, or complete as many repetitions as possible in a certain amount of time. For that reason, it’s REALLY easy to sacrifice form in exchange for finishing the workout quicker. If you don’t have somebody spotting you or telling you to keep your form correct, then you’re in trouble.

I often get caught up in focusing on numbers and scales, so I decided not to officially weigh myself before or after Whole30. But I can attest that everything about my body just felt better. I know saying something like "I lost eleven pounds" would sound much more convincing, but I could see that my stomach was slimmer, as was my face (which is awkwardly the first place I gain weight).


Autoimmunity is a process in which our bodies own immune system attacks “us.” Normally the immune system protects us from bacterial, viral, and parasitic infections. The immune system identifies a foreign invader, attacks it, and ideally clears the infection. A good analogy for autoimmunity is the case of tissue rejection after organ donation. If someone requires a new heart, lung kidney or liver due to disease or injury, a donor organ may be an option. The first step in this process is trying to find a tissue “match”. All of us have molecules in our tissues that our immune system uses to recognize self from non-self. If a donated organ is not close enough to the recipient in tissue type the immune system will attack and destroy the organ. In autoimmunity, a similar process occurs in that an individuals own tissue is confused as something foreign and the immune system attacks this “mislabeled” tissue. Common forms of autoimmunity include Multiple Sclerosis, Rheumatoid Arthritis, Lupus, and Vitiligo to name only a tiny fraction of autoimmune diseases. Elements of autoimmunity are likely at play in conditions as seemingly unrelated as Schizophrenia, infertility, and various forms of cancer.
CrossFit is promoted as both a physical exercise philosophy and a competitive fitness sport, incorporating elements from high-intensity interval training, Olympic weightlifting, plyometrics, powerlifting, gymnastics, girevoy sport, calisthenics, strongman, and other exercises. It is practiced by members of over 13,000[6] affiliated gyms,[7] roughly half of which are located in the United States,[8] and by individuals who complete daily workouts (otherwise known as "WODs" or "workouts of the day").[9][10] CrossFit has been criticized for allegedly causing people to suffer from unnecessary injuries and exertional rhabdomyolysis.[11][12][13]
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