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Originally, teams were awarded the "Affiliate Cup" for having the best overall score from the individual athletes that had come from the same CrossFit-affiliated gym. In 2009, the Games began having a separate set of events for affiliate teams and consisted of four to six athletes from the same gym.[30] The next season, the format was finalized to teams of three men and three women. In the 2018 games, each team was changed to four members, two men and two women.[17] In 2019, CrossFit removed the stipulation that team members had to be from the same affiliate. Teams are subject to a similar qualification process as the individuals.[20]
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Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.
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