The WHO trial (so named because the international team of principal investigators contained World Health Organization members) tested the potential of clofibrate, a “pre-statin” cholesterol-lowering agent, to reduce heart attack morbidity and mortality. The investigators ultimately concluded that clofibrate "cannot be recommended as a lipid-lowering drug for community-wide primary prevention of ischaemic heart disease.” Nevertheless, clofibrate remained in use until 2002, when it was pulled for increasing cancer rates. In their review of studies such as the WHO trial, Uffe Ravnskov and David Diamond observe, “Despite the largely disappointing findings from 50 years of cholesterol lower[ing] trials, the indictment and conviction of cholesterol as the causal agent in CVD [cardiovascular disease] has stood the test of time. … [Yet] the grand effort to reduce cholesterol as a strategy to improve health has failed.”
But then again, when have you found a program that is ENTIRELY ONLINE AND MOSTLY FREE that changes your life? When you are in line at the checkout with your meat and chicken thighs and raw almonds, remember the money you are going to save by NOT joining another weight-loss program or hiring a life coach or drinking booze or going to the doctor for that blood pressure you really ought to monitor which is quite possibly linked to your diet. Dallas and Melissa, the authors, say that a craving usually lasts about ten seconds. Count and breathe through the french fries someone raved about at the office. Skip out for a tiny walk while everyone is hoarding that cake at work. Eat a little roast turkey and some oven-baked potatoes. Read more books with the newfound energies. If I--a bon vivant of the kitchen, believe me, hoarder of butter, lover of booze, cream, sugar--can give these things up for thirty days, anyone can.
A metaresearch group at Tilburg University in the Netherlands investigates scientists’ research methods and operations, scrutinizing questionable practices such as selective reporting of statistical tests and data massaging. The group instead advocates for practices such as preregistering studies and making experimental data immediately available for open external review and verification. Its members are optimistic that “the perverse incentives of careerist academia, to hoard data and sacrifice rigor for headline-generating findings, will ultimately be fixed.”