Autoimmunity is a process in which our bodies own immune system attacks “us.” Normally the immune system protects us from bacterial, viral, and parasitic infections. The immune system identifies a foreign invader, attacks it, and ideally clears the infection. A good analogy for autoimmunity is the case of tissue rejection after organ donation. If someone requires a new heart, lung kidney or liver due to disease or injury, a donor organ may be an option. The first step in this process is trying to find a tissue “match”. All of us have molecules in our tissues that our immune system uses to recognize self from non-self. If a donated organ is not close enough to the recipient in tissue type the immune system will attack and destroy the organ. In autoimmunity, a similar process occurs in that an individuals own tissue is confused as something foreign and the immune system attacks this “mislabeled” tissue. Common forms of autoimmunity include Multiple Sclerosis, Rheumatoid Arthritis, Lupus, and Vitiligo to name only a tiny fraction of autoimmune diseases. Elements of autoimmunity are likely at play in conditions as seemingly unrelated as Schizophrenia, infertility, and various forms of cancer.
An early client of Glassman's described the CrossFit experience as "agony coupled with laughter." Glassman liked that. It was as if his increasingly fit posse had a subversive secret: combinations of exercises that seemed strange and reckless and maybe dangerous to the ignorant. When Elizer, who volunteered to build the website, asked Glassman if he had a logo in mind, Glassman thought about the idea of agony mixed with laughter, then thought about thumbing his nose at all the ho-hum personal trainers he had ever endured. He came up with a vomiting clown. He called it Uncle Pukie.
Workout 2 Part A begins with the dumbbells on the floor and the athlete standing behind their dumbbells. At the start of the ascending 20min clock, the athlete may pick up their dumbbells and begin the workout. Upon completion of the first set of deadlifts, the athlete will move to the burpee box over. Athletes may take as many sets, breaking up the work as needed, to complete the required number of repetitions throughout the workout.
You're not tracking calories. You won't feel hungry. You won't be eating based on a points system. You're going to miss your morning doughnuts, but this isn't like any diet you might be used to. Whole30 co-founder Melissa Hartwig actually doesn't like calling the Whole30 a "diet" at all. “Most diets are spent white-knuckling your way through deprivation, restriction, hunger, tuning out your body’s signals, and obsessing over tracking and weighing your food,” Hartwig says. She doesn't think that type of behavior is sustainable, and if you've ever tried dieting, you probably agree.
A metaresearch group at Tilburg University in the Netherlands investigates scientists’ research methods and operations, scrutinizing questionable practices such as selective reporting of statistical tests and data massaging. The group instead advocates for practices such as preregistering studies and making experimental data immediately available for open external review and verification. Its members are optimistic that “the perverse incentives of careerist academia, to hoard data and sacrifice rigor for headline-generating findings, will ultimately be fixed.”