Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.
In 2011, the Games adopted an online qualification format, facilitating participation by athletes worldwide. During the five-week-long "CrossFit Open", one new workout is released each week. Athletes have several days to complete the workout and submit their scores online, with either a video or validation by a CrossFit affiliate. Since the Open is available to any level of athlete, many affiliates encourage member participation and the number of worldwide participants can be in the hundreds of thousands.
Do not consume baked goods, junk foods, or treats with “approved” ingredients. Recreating or buying sweets, treats, and foods-with-no-brakes (even if the ingredients are technically compliant) is totally missing the point of the Whole30, and will compromise your life-changing results. These are the same foods that got you into health-trouble in the first place—and a pancake is still a pancake, even if it’s made with coconut flour.
We also talked about our meals, our struggles, and the results we were seeing from Whole30. Mentally, I felt more clear-headed and emotionally stable. I slept deeper and remembered more of my dreams, something that tends to never happen. (In one dream, I accidentally ate a slice of pizza and cried about it because if you break your Whole30 diet, you're supposed to start again from Day 1.)
To the outside world, though, as Glassman's company has exploded from a cult fitness website to a gym concept primed to have more locations than Curves by the end of 2013, CrossFit can appear risky, unhinged: Here is a fitness routine that has sent people to the hospital, overseen by people who may have had no more than two days of instruction. (Although every real trainer I met had considerable experience and was genuinely excellent, I attended the seminar and passed the test on my fourth day reporting this story. I am, believe me, no fitness savant.) And it's all led by a man who, in a 2006 CrossFit.com comment, wrote, "We have a therapy for injuries at CrossFit called STFU." As in, Shut the f-k up. That's enough to make even the most devoted laissez faire-ists get a little, well, Uncle Pukie.
The Dietitian's Guide to Eating Bugs by Daniel Calder is a comprehensive guide to the nutritional content of insects. He believes insect breeding and consumption are important elements sustainable living, particularly when it comes to complementing foraged plant material with meat products. Numerous insects contain nutrients similar to those found in more conventional livestock, except the feed to conversion ratio is much higher and they're much cheaper to breed. You can find the book at scribd. Also available in e-book format for $35.
For many years Arthur De Vany Ph.D. has been writing a book called Evolutionary Fitness on "What Evolution Teaches Us About How to Live and Stay Healthy." The diet he follows fits into my core diet definition. He may have been the first one to use the paleo diet to maximize fitness. His current site is Art's Blog on Fitness, Health, Aging, Nutrition and Exercise [archive.org].
Update: So I just finished my first whole30 round and I have to say that I'm super excited by the results. When I hopped on the scale today, I noticed that I had lost 26.6 pounds. I then measured myself and noted that I lost a total of 31.5 inches (-5" from chest, -2" from right arm, -3.5" from left arm, -8" from waist, -5" from hips, -4" from right thigh, and -4" from left thigh). I am really excited by my results!
^ Hall, Harriet (2014). "Food myths: what science knows (and does not know) about diet and nutrition". Skeptic. 19 (4). p. 10. Fad diets and "miracle" diet supplements promise to help us lose weight effortlessly. Different diet gurus offer a bewildering array of diets that promise to keep us healthy and make us live longer: vegan, Paleo, Mediterranean, low fat, low carb, raw food, gluten-free ... the list goes on. (subscription required)
CrossFit headquarters' aggression can be enough to stunt interest in the WOD--almost. In April 2012, two avid CrossFitters, Jason and Shannon Janke, opened up the PR Cave, a sporting goods store in Yorba Linda, California, designed to cater to boxgoers all around Orange County. In November, they added a sign, "Where CrossFitters Shop," and had the slogan printed on mixer bottles for protein shakes. On January 16, they received a cease-and-desist from CrossFit, objecting to the use of CrossFitter. A month later, CrossFit filed suit.
Following the paleo diet can be pricey. Inexpensive and healthy non-meat protein sources like soy and beans are off-limits, and a recent BMJ Open study shows that healthy meats like lean ground beef and boneless, skinless chicken breasts cost an average of 29 cents more per serving compared to less-healthy ones, such as high-fat ground beef and chicken drumsticks. Even switching from peanut butter to paleo-approved almond butter will cost you—it goes for up to $13 a jar.
You start to talk a language nobody understands – talking to a CrossFitter is like talking to somebody in a foreign language. CrossFit people oftentimes forget that nobody outside of CF understands what half the stuff they say means, so they shout out achievements or accomplishments and explain how quickly they did specific exercises…but they don’t realize nobody really cares!
Smoothies are generally discouraged on Whole30. However, if you must have one, choose a recipe with no added sweeteners and low-sugar fruits. This smoothie is more scoopable with a spoon, so you can slow down and savor it (important on Whole30!). The only sweet flavor comes from fresh raspberries — plus, this packs your bowl with fats from avocado and coconut milk.
Lastly, HAVE FUN. I believe strongly that the lifestyle changes that really “stick” are the ones that are fun and exciting. Continue to foster your culinary curiosity, and play around in the kitchen. Not only will you eat healthier, but you’ll develop skills and gain knowledge that’ll make you even more awesome than you are right now (as if that’s even possible).
But then again, when have you found a program that is ENTIRELY ONLINE AND MOSTLY FREE that changes your life? When you are in line at the checkout with your meat and chicken thighs and raw almonds, remember the money you are going to save by NOT joining another weight-loss program or hiring a life coach or drinking booze or going to the doctor for that blood pressure you really ought to monitor which is quite possibly linked to your diet. Dallas and Melissa, the authors, say that a craving usually lasts about ten seconds. Count and breathe through the french fries someone raved about at the office. Skip out for a tiny walk while everyone is hoarding that cake at work. Eat a little roast turkey and some oven-baked potatoes. Read more books with the newfound energies. If I--a bon vivant of the kitchen, believe me, hoarder of butter, lover of booze, cream, sugar--can give these things up for thirty days, anyone can.